The bus journey time between fort lauderdale and key west (island) is around 5h 21m and covers a distance of around 195 miles. The best way to make it to key west and see all the other good stuff in south florida is by car. Miami To Key West Road Trip Florida Keys Itinerary Stops In 2021 Florida Keys Road Trip Trip Road Trip Fun These costs include accommodation (assuming double occupancy, so the traveler is sharing the room), food, transportation, and entertainment. How to travel from fort lauderdale to key west . The fastest journey normally takes 5h 30m. Traveling by bus from fort lauderdale to key west usually takes around 5 hours and 50 minutes, but the fastest flixbus us bus can make the trip in 4 hours and 20 minutes. Some of our most popular key west tourist activities on the water include dolphin encounters, kayaking the backcountry, diving and snorkeling at ft. This includes an average layover time of around 11 min. Rome2rio displays up to date schedules, route m...