Basically, you’re going to drive highway 1 from san francisco to los angeles. When you reach santa barbara, you’ll continue onto highway 101 for a short stretch and then hop back on highway 1 to drive through glitzy malibu into los angeles. 13 Incredible Stops On A Pacific Coast Highway Road Trip Pacific Coast Highway Road Trip California Travel Road Trips California Coast Road Trip The san francisco to los angeles road trip down highway 1 drive is an iconic drive through some of the most beautiful parts of california. Los angeles to san francisco drive highway 1 . This stretch of pch1 passes through the beautiful big sur region which is the #1 attraction along the route, plus the cities of los angeles and san francisco are very easy to fly in or out. For instance, if you’re traveling from san francisco to los angeles, be sure to take highway 1 both directions. In retrospect, it’s a much more suitable as a weekend getaway trip destination from san francisco. Below are the ...